and related terms
Video: Search by Themes (YouTube)
(2 min 40 sec) Recorded April 2014 Transcript
Most research articles will identify where more research is needed. To identify research trends, use the literature review matrix to track where further research is needed.
There is no consistent section in research articles where the authors identify where more research is needed. Pay attention to these sections:
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Susanne hempel.
* RAND Corporation, Evidence-based Practice Center (EPC), Santa Monica
† University of Southern California, Keck School of Medicine, Los Angeles, CA
‡ RAND, National Security Research Division, Arlington
§ Defense Health Agency, Psychological Health Center of Excellence (PHCoE), Falls Church, VA
Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website, www.lww-medicalcare.com .
Supplemental Digital Content is available in the text.
Evidence synthesis is key in promoting evidence-based health care, but it is resource-intense. Methods are needed to identify and prioritize evidence synthesis needs within health care systems. We describe a collaboration between an agency charged with facilitating the implementation of evidence-based research and practices across the Military Health System and a research center specializing in evidence synthesis.
Scoping searches targeted 15 sources, including the Veterans Affairs/Department of Defense Guidelines and National Defense Authorization Acts. We screened for evidence gaps in psychological health management approaches relevant to the target population. We translated gaps into potential topics for evidence maps and/or systematic reviews. Gaps amenable to evidence synthesis format provided the basis for stakeholder input. Stakeholders rated topics for their potential to inform psychological health care in the military health system. Feasibility scans determined whether topics were ready to be pursued, that is, sufficient literature exists, and duplicative efforts are avoided.
We identified 58 intervention, 9 diagnostics, 12 outcome, 19 population, and 24 health services evidence synthesis gaps. Areas included: posttraumatic stress disorder (PTSD) (19), suicide prevention (14), depression (9), bipolar disorder (9), substance use (24), traumatic brain injury (20), anxiety (1), and cross-cutting (14) synthesis topics. Stakeholder input helped prioritize 19 potential PTSD topics and 22 other psychological health topics. To date, 46 topics have undergone feasibility scans. We document lessons learned across clinical topics and research methods.
We describe a transparent and structured approach to evidence synthesis topic selection for a health care system using scoping searches, translation into evidence synthesis format, stakeholder input, and feasibility scans.
Evidence synthesis is an essential step in promoting evidence-based medicine across health systems; it facilitates the translation of research to practice. A systematic review of the research literature on focused review questions is a key evidence synthesis approach that can inform practice and policy decisions. 1 However, systematic reviews are resource-intense undertakings. In a resource-constrained environment, before an evidence review is commissioned, the need and the feasibility of the review must be established.
Establishing the need for the review can be achieved through a research gap analysis or needs assessment. Identification of a gap serves as the first step in developing a new research question. 2 Research gaps in health care do not necessarily align directly with research needs. Research gaps are only critical where knowledge gaps substantially inhibit the decision-making ability of stakeholders such as patients, health care providers, and policymakers, thus creating a need to fill the knowledge gap. Evidence synthesis enables the assessment of whether a research gap continues to exist or whether there is adequate evidence to close the knowledge gap.
Furthermore, a gap analysis often identifies multiple, competing gaps that are worthwhile to be pursued. Given the resource requirements of formal evidence reviews, topic prioritization is needed to best allocate resources to those areas deemed the most relevant for the health system. Regardless of the topic, the prioritization process is likely to be stakeholder-dependent. Priorities for evidence synthesis will vary depending on the mission of the health care system and the local needs of the health care stakeholders. A process of stakeholder input is an important mechanism to ensure that the evidence review will meet local needs as well to identify a receptive audience of the review findings.
In addition to establishing the need for an evidence review, the feasibility of conducting the review must also be established. In conducting primary research, feasibility is often mainly a question of available resources. For evidence reviews, the resources, the availability of primary research, and the presence of existing evidence reviews on the topic need to be explored. Not all topics are amenable for a systematic review which focus on a specific range of research questions and rely heavily on published literature. Furthermore, evidence review synthesizes the existing evidence; hence, if there is insufficient evidence in the primary research literature, an evidence review is not useful. Establishing a lack of evidence is a worthwhile exercise since it identifies the need for further research. However, most health care delivery organizations will be keen to prioritize areas that can be synthesized, that is, investing in synthesizing a body of research sizable enough to derive meaningful results. For evidence reviews, the presence of existing evidence syntheses is also an important consideration, in particular, to determine the incremental validity of a new review. Although primary research benefits profoundly by replication, secondary literature, in particular in the context of existing high-quality reviews and/or limited evidence, may not add anything to our knowledge base. 3
This work describes a structured and transparent approach to identify and prioritize areas of psychological health that are important and that can be feasibly addressed by a synthesis of the research literature. It describes a collaboration between an agency charged with facilitating the implementation of evidence-based research and practices across the Military Health System (MHS) and a research center specializing in evidence synthesis.
This project is anchored in the relationship between the Defense Health Agency Psychological Health Center of Excellence (PHCoE) and the RAND Corporation’s National Defense Research Institute (NDRI), one of the Federally Funded Research and Development Centers (FFRDC) dedicated to providing long-term analytic support to the Defense Health Agency. PHCoE, an agency charged with facilitating the implementation of evidence-based research and practices across the Military Health System funded a series of systematic reviews and evidence maps synthesizing psychological research. The project draws on the expertise of the Southern California Evidence-based Practice Center (EPC) located at RAND, a center specializing in evidence synthesis. The project included scoping searches, stakeholder input, and feasibility scans. The project is ongoing; this manuscript describes methods and results from June 2016 to September 2018. The project was assessed by our Human Subject Protection staff and determined to be exempt (date July 7, 2016, ID ND3621; August 6, 2017, ID ND3714).
The following describes the process, Figure Figure1 1 provides a visual overview.
Process of identifying research gaps and prioritizing psychological health evidence synthesis needs.
Scoping searches targeted pertinent sources for evidence gaps. The searches focused on clinical conditions and interventions relevant to psychological health, including biological psychiatry, health care services research, and mental health comorbidity. Proposed topics and study populations were not limited by deployment status or deployment eligibility, but the topic section considered the prevalence of clinical conditions among Department of Defense active duty military personnel managed by the MHS. The scoping searches excluded evidence gaps addressing children and adolescents and clinical conditions exclusively relevant to veterans managed by the Department of Veterans Affairs.
We screened 15 sources in total for evidence synthesis gaps.
Veterans Affairs/Department of Defense clinical practice guidelines were a key source for documented evidence gaps. 4 – 9 Recently updated guidelines were screened only for evidence gaps that indicated a lack of synthesis of existing research or content areas that were outside the scope of that guideline (guidelines rely primarily on published systematic reviews and can only review a limited number of topic areas).
We consulted the current report of the committee on armed services of the House of Representatives regarding the proposed National Defense Authorization Act (NDAA) and the report for the upcoming fiscal year. 10 , 11 We specifically screened the report for research priorities identified for psychological health. We also screened the published National Research Action Plan designed to improve access to mental health services for veterans, service members, and military families. 12
We conducted a literature search for publications dedicated to identifying evidence gaps and research needs for psychological health and traumatic brain injury. We searched for publications published since 2000–2016 in the most relevant databases, PubMed and PsycINFO, that had the words research gap, knowledge gap, or research priority in the title and addressed psychological health (Supplemental Digital Content, http://links.lww.com/MLR/B836 ). The search retrieved 203 citations. Six publications were considered potentially relevant and obtained as full text, 1 source was subsequently excluded because the authors conducted a literature search <3 years ago and it was deemed unlikely that a new review would identify substantially more eligible studies. 13 – 19
We also used an analysis of the utilization of complementary and alternative medicine in the MHS 20 to identify interventions that were popular with patients but for which potentially little evidence-based guidance exists. We focused our scoping efforts on complementary approaches such as stress management, hypnotherapy, massage, biofeedback, chiropractic, and music therapy to align with the funding scope. In the next step, we reviewed the existing clinical practice guidelines to determine whether clinicians have guidance regarding these approaches. The Department of Defense Health Related Behaviors Survey of Active Duty Military Personnel 21 is an anonymous survey conducted every 3 years on service members with the aim of identifying interventions or health behaviors patients currently use. To address evidence gaps most relevant to patients, we screened the survey results, and then matched the more prevalent needs identified with guidance provided in relevant clinical practice guidelines.
We consulted the priority review list assembled by the Cochrane group to identify research needs for systematic reviews. We screened the 2015–2017 lists for mental health topics that are open to new authors, that is, those that do not have an author team currently dedicated to the topic. None of the currently available topics appeared relevant to psychological health and no topics were added to the table. We also consulted with ongoing federally funded projects to identify evidence gaps that were beyond the scope of the other projects. In addition, we screened a list of psychological health research priorities developed at PHCoE for knowledge gaps that could be addressed in systematic reviews or evidence maps. Finally, we screened resources available on MHS web sites for evidence gaps.
We first screened these sources for knowledge gaps, regardless of considerations of whether the gap is amenable to evidence review. However, we did not include research gaps where the source explicitly indicated that the knowledge gap is due to the lack of primary research. We distinguished 5 evidence gap domains and abstracted gaps across pertinent areas: interventions or diagnostic questions, treatment outcomes or specific populations, and health services research and health care delivery models.
We then translated the evidence gaps into potential topics for evidence maps and/or systematic reviews. Evidence maps provide a broad overview of large research areas using data visualizations to document the presence and absence of evidence. 22 Similar to scoping reviews, evidence maps do not necessarily address the effects of interventions but can be broader in scope. Systematic reviews are a standardized research methodology designed to answer clinical and policy questions with published research using meta-analysis to estimate effect sizes and formal grading of the quality of evidence. We considered systematic reviews for effectiveness and comparative effectiveness questions regarding specific intervention and diagnostic approaches.
Evidence synthesis gaps that were determined to be amenable to systematic review or evidence map methods provided the basis for stakeholder input. Although all topics were reviewed by project personnel, we also identified psychological health service leads for Army, Navy, Air Force, and Marines within the Defense Health Agency as key stakeholders to be included in the topic selection process. To date, 2 rounds of formal ratings by stakeholders have been undertaken.
The first round focused on the need for systematic review covering issues related to posttraumatic stress disorder (PTSD). The second round focused on other potential psychological health topics determined to be compatible with the MHS mission. Represented clinical areas were suicide prevention and aftercare, depressive disorders, anxiety disorders, traumatic brain injury, substance use disorder including alcohol and opioid use disorder, and chronic pain. All of the potential topics addressed either the effects of clinical interventions or health service research questions.
Stakeholders rated the topics based on their potential to inform psychological health care in the military health system. The raters used a scale 5-point rating scale ranging from “No impact” to “Very high impact.” In addition, stakeholders were able to add additional suggestions for evidence review. We analyzed the mean, the mode, and individual stakeholder rating indicating “high impact” for individual topics.
Feasibility scans provided an estimate of the volume and the type of existing research literature which is informative for 3 reasons. First, this process determined whether sufficient research was available to inform a systematic review or an evidence map. Second, feasibility scans can provide an estimate of the required resources for an evidence review by establishing whether only a small literature base or a large number of research studies exists. Finally, feasibility scans identify existing high-profile evidence synthesis reports that could make a new synthesis obsolete.
Feasibility scans for potential evidence maps concentrated on the size of the body of research that would need to be screened and the relevant synthesis questions that can inform how this research should be organized in the evidence map. Feasibility scans for systematic reviews aimed to determine the number of relevant studies, existing high-quality reviews, and the number of studies not covered in existing reviews. Randomized controlled trials (RCTs) are the focus of most of the systematic review topics, that is, strong research evidence that could inform clinical practice guideline committees to recommend either for or against interventions. An experienced systematic reviewer used PubMed, a very well-maintained and user-friendly database for biomedical literature, developed preliminary search strategies, and applied database search filters (eg, for RCTs or systematic reviews) in preliminary literature searches to estimate the research volume for each topic.
Scans also identified any existing high-quality evidence review published by agencies specializing in unbiased evidence syntheses such as the Agency for Healthcare Research and Quality (AHRQ)’s Evidence-based Practice Center program, the Cochrane Collaboration, the Campbell Collaboration, the Evidence Synthesis Program of the Department of Veterans Affairs, and the Federal Health Technology Assessment program. We used the databases PubMed and PubMed Health to identify reports. We appraised the scope, relevance and publication year of the existing high-profile evidence reviews. The research base for psychological health develops rapidly and evidence syntheses need to ensure that current clinical policies reflect the best available evidence. When determining the feasibility and appropriateness of a new systematic review, we took the results of the original review and any new studies that had been published subsequent to the systematic review on the same topic into account.
The following results are described: the results of the scoping searches and gap analysis, the translation of gaps into evidence synthesis format, the stakeholder input ratings, and the feasibility scans.
The scoping search and gap analysis identified a large number of evidence gaps as documented in the gap analysis table in the Appendix (Supplemental Digital Content, http://links.lww.com/MLR/B836 ). Across sources, we identified 58 intervention, 9 diagnostics, 12 outcome, 19 population, and 24 health services evidence synthesis gaps. The evidence gaps varied considerably with regard to scope and specificity, for example, highlighting knowledge gaps in recommendations for medications for specific clinical indications or treatment combinations 4 to pointing out to gaps in supporting caregivers. 11 The largest group of evidence gaps were documented for interventions. This included open questions for individual interventions (eg, ketamine) 12 as well as the best format and modality within an intervention domain (eg, use of telehealth). 6 Diagnostic evidence gaps included open questions regarding predictive risk factors that could be used in suicide prevention 8 and the need for personalized treatments. 12 Outcome evidence gaps often pointed to the lack of measured outcomes to include cost-effectiveness as well as the lack of knowledge on hypothesized effects, such as increased access or decreased stigma associated with technology-based modalities. 23 Population evidence gaps addressed specific patient populations such as complex patients 5 and family members of service members. 11 The health services evidence gaps addressed care support through technology (eg, videoconferencing 23 ) as well as treatment coordination within health care organizations such as how treatment for substance use disorder should be coordinated with treatment for co-occurring conditions. 4
The gaps were translated into potential evidence map or systematic review topics. This translation process took into account that some topics cannot easily be operationalized as an evidence review. For example, knowledge gaps regarding prevalence or utilization estimates were hindered by the lack of publicly available data. In addition, we noted that some review questions may require an exhaustive search and a full-text review of the literature because the information cannot be searched for directly, and hence were outside the budget restraints.
The clinical areas and number of topics were: PTSD (n=19), suicide prevention (n=14), depression (n=9), bipolar disorder (n=9), substance use (n=24), traumatic brain injury (n=20), anxiety (n=1), and cross-cutting (n=14) evidence synthesis topics. All topic areas are documented in the Appendix (Supplemental Digital Content, http://links.lww.com/MLR/B836 ).
Stakeholders rated 19 PTSD-related research gaps and suggested an additional 5 topics for evidence review, addressing both preventions as well as treatment topics. Mean ratings for topics ranged from 1.75 to 3.5 on a scale from 0 (no impact potential) to 4 (high potential for impact). Thus, although identified as research gaps, the potential of an evidence review to have an important impact on the MHS varied across the topics. Only 2 topics received a mean score of ≥3 (high potential), including predictors of PTSD treatment retention and response and PTSD treatment dosing, duration, and sequencing . In addition, raters’ opinions varied considerably across some topics with SDs ranging from 0.5 to 1.5 across all topics.
The stakeholders rated 22 other psychological health topics, suggested 2 additional topics for evidence review, and revised 2 original topics indicating which aspect of the research gap would be most important to address. Mean scores for the rated topics ranged from 0.25 to 3.75, with the SDs for each item ranging from 0 to 1.4. Six topics received an average score of ≥3, primarily focused on the topics of suicide prevention, substance use disorders, and telehealth interventions. Opinions on other topics varied widely across service leads.
Evidence review topics that were rated by stakeholders as having some potential for impact (using a rating cutoff score>1) within the MHS were selected for formal feasibility scans. To date, 46 topics have been subjected to feasibility scans. Of these, 11 were evaluated as potential evidence map, 17 as a systematic review, and 18 as either at the time of the topic suggestion. The results of the feasibility scans are documented in the table in the Appendix (Supplemental Digital Content, http://links.lww.com/MLR/B836 ).
The feasibility scan result table shows the topic, topic modification suggestions based on literature reviews, and the mean stakeholder impact rating. The table shows the employed search strategy to determine the feasibility; the estimated number of RCTs in the database PubMed; the number and citation of Cochrane, Evidence Synthesis Program, and Health Technology Assessment reviews, that is, high-quality syntheses; and the estimated number of RCTs published after the latest existing systematic review that had been published on the topic.
Each potential evidence review topic was discussed in a narrative review report that documented the reason for determining the topic to be feasible or not feasible. Reasons for determining the topic to be not feasible included the lack of primary research for an evidence map or systematic review, the presence of an ongoing research project that may influence the evidence review scope, and the presence of an existing high-quality evidence review. Some topics were shown to be feasible upon further modification; this included topics that were partially addressed in existing reviews or topics where the review scope would need to be substantially changed to result in a high-impact evidence review. Topics to be judged feasible met all outlined criteria, that is, the topic could be addressed in a systematic review or evidence map, there were sufficient studies to justify a review, and the review would not merely replicate an existing review but make a novel contribution to the evidence base.
The project describes a transparent and structured approach to identify and prioritize evidence synthesis topics using scoping reviews, stakeholder input, and feasibility scans.
The work demonstrates an approach to establishing and evaluating evidence synthesis gaps. It has been repeatedly noted that research gap analyses often lack transparency with little information on analytic criteria and selection processes. 24 , 25 In addition, research need identification may not be informed by systematic literature searches documenting gaps but primarily rely on often unstructured content expert input. 26 , 27 Evidence synthesis needs assessment is a new field that to date has received very little attention. However, as health care delivery organizations move towards providing evidence-based treatments and the existing research continue to grow, both evidence reviews and evidence review gap identification and prioritization will become more prominent.
One of the lessons learned is that the topic selection process added to the timeline and required additional resources. The scoping searches, translation into evidence synthesis topics, stakeholder input, and feasibility scans each added time and the project required a longer period of performance compared to previous evidence synthesis projects. The project components were undertaken sequentially and had to be divided into topic areas. For example, it was deemed too much to ask for stakeholder input for all 122 topics identified as potential evidence review topics. Furthermore, we needed to be flexible to be able to respond to unanticipated congressional requests for evidence reviews. However, our process of identifying synthesis gaps, checking whether topics can be translated into syntheses, obtaining stakeholder input to ensure that the gaps are meaningful and need filling, and estimating the feasibility and avoiding duplicative efforts, has merit considering the alternative. More targeted funding of evidence syntheses ensures relevance and while resources need to be spent on the steps we are describing, these are small investments compared to the resources required for a full systematic review or evidence map.
The documented stakeholder engagement approach was useful for many reasons, not just for ensuring that the selection of evidence synthesis topics was transparent and structured. The stakeholders were alerted to the evidence synthesis project and provided input for further topic refinement. This process also supported the identification of a ‘customer’ after the review was completed, that is, a stakeholder who is keen on using the evidence review is likely to take action on its results and ready to translate the findings into clinical practice. The research to practice gap is substantial and the challenges of translating research to practice are widely documented. 28 – 30 Inefficient research translation delays delivery of proven clinical practices and can lead to wasteful research and practice investments.
The project had several strengths and limitations. The project describes a successful, transparent, and structured process to engage stakeholders and identifies important and feasible evidence review topics. However, the approach was developed to address the specific military psychological health care system needs, and therefore the process may not be generalizable to all other health care delivery organizations. Source selection was tailored to psychological health synthesis needs and process modifications (ie, sources to identify gaps) are needed for organizations aiming to establish a similar procedure. To keep the approach manageable, feasibility scans used only 1 database and we developed only preliminary, not comprehensive searches. Hence, some uncertainty about the true evidence base for the different topics remained; feasibility scans can only estimate the available research. Furthermore, the selected stakeholders were limited to a small number of service leads. A broader panel of stakeholders would have likely provided additional input. In addition, all evaluations of the literature relied on the expertise of experienced systematic reviewers; any replication of the process will require some staff with expertise in the evidence review. Finally, as outlined, all described processes added to the project timeline compounding the challenges of providing timely systematic reviews for practitioners and policymakers. 31 , 32
We have described a transparent and structured approach to identify and prioritize areas of evidence synthesis for a health care system. Scoping searches and feasibility scans identified gaps in the literature that would benefit from evidence review. Stakeholder input helped ensure the relevance of review topics and created a receptive audience for targeted evidence synthesis. The approach aims to advance the field of evidence synthesis needs assessment.
Acknowledgments.
The authors thank Laura Raaen, Margaret Maglione, Gulrez Azhar, Margie Danz, and Thomas Concannon for content input and Aneesa Motala and Naemma Golshan for administrative assistance.
Supported by the Office of the Secretary of Defense, Psychological Health Center of Excellence. The findings and conclusions in this manuscript are those of the authors and do not necessarily represent the views of the Psychological Health Center of Excellence, the Office of the Secretary of Defense, or the United States government.
The authors declare no conflict of interest.
Write Like a Scientist
A Guide to Scientific Communication
A gap is something that remains to be done or learned in an area of research; it’s a gap in the knowledge of the scientists in the field of research of your study. Every research project must, in some way, address a gap–that is, attempt to fill in some piece of information missing in the scientific literature. Otherwise, it is not novel research and is therefore not contributing to the overall goals of science.
A gap statement is found in the Introduction section of a journal article or poster or in the Goals and Importance section of a research proposal and succinctly identifies for your audience the gap that you will attempt to address in your project.
A gap might be a lack of understanding about how well a particular instrument works in a certain situation. It could be introducing a new method that needs to be tested. Or it could be that you are studying a whole new organism, system, or part of a process. Your project may also address multiple gaps, in which case you should be sure to identify each of them clearly!
In a class, you might not always be studying something brand “new.” But, in most cases, you should still try to come up with something unique about your project, however small. Talk to your professor about what they expect for your gap statement if nothing seems to work.
: “… The relationship between the four damping factors, i.e. internal friction, support loss, airflow force in free space, and squeeze force, has not yet been clarified, so it is not obvious which one is dominant in actual microsystems.” |
Here, the authors signal to us that this is a gap because they use the words “has not yet been clarified.” Other phrases that might help you identify (or form!) a gap statement are:
Once you identify the gap in the literature, you must tell your audience how you attempt to at least somewhat address in your project this lack of knowledge or understanding . In a journal article or poster, this is often done in a new paragraph and should be accomplished in one summary statement, such as:
Therefore, the purpose of this study was to determine the effects of lead on the hepatobiliary system, especially on the liver and on the gallbladder (adapted from Sipos et al. 2003 ).
You’ll often find that the first sentence of the last paragraph in a paper’s introduction will start somewhat like this, indicating the gap fill.
Some phrases you can use to indicate your gap “fill:” |
Remember–always keep your voice professional! Colloquial phrases such as “we looked into” or “we checked if” should be avoided when introducing your gap fill.
So let’s look at this idea in context by looking at some examples from a couple of types of papers. The gap statements are underlined; the fills are italicized.
Adapted from : Though ideally expected to be chemically very stable due to the poor reactivity of the basal aromatic plane from which SWNTs are built, the question of whether all the chemicals which are now currently proposed in the literature as purifying, suspending, or grafting agents for SWNTs actually have a limited effect on the SWNT integrity has to be addressed. Adapted from : Milly’s work recognized the importance of storage capacity of the root zone in controlling evapotranspiration and has the postential for assessing the catchment-scale response of vegetation changes. However, the practical application of this model is limited because of the complex numerical solutions required. Adapted from : A risk assessment of the potential impacts on health and environment that the production, use, and disposal of nanomaterials may engender requires information concerning both the potential for exposure to a given material and its (once exposed) potential impacts such as toxicity or mutagenicity. |
In the second and third examples, the gap may be a little less obvious–it doesn’t use any phrases to signal to you that there’s something missing, such as “has not been clarified” or “have not been reported.” But because of the way the paragraph is laid out–following the conventions of our move structures–we can see that the underlined section of text is indeed the missing information in the literature that the group sought to address in their project.
[bg_faq_start] In the following examples, identify the gap statement. Then, identify the fill. Notice if there are any specific words or phrases used to signal either of these moves. 1. Adapted from : Paralytic shellfish poisoning occurs worldwide, and harmful algal blooms, including those responsible for PSP, appear to be increasing in frequency and intensity. PSP outbreaks in Portuguese waters have been associated with blooms of Gymnodinium caenatum in the late 1980s to early 1990s, then again after 2005. According to the national monitoring program in Portugal, G. catenatum were not reported along the Portuguese coast during the 10-year period from 1995 to 2005. The aims of this study were to fully characterize the toxin profile of G. catenatum strains isolated from the NW Portuguese coast before and after the 10-year absence of blooms to 2. Adapted from : The exchange process frequently observed in polypyrrane condensations is proposed to occur by the acid-catalyzed fragmentation of a polypyrrane into pyrrolic and azafulvene components.15 As illustrated in Scheme 2, recombination of and can form a new polypyrrane that cannot be formed by direct condensation of the dipyrromethane and aldehyde. Ultimately this process leads to the production of a scrambled mixture of porphyrins. The factors that promote the scrambling process in MacDonald-type 2 + 2 condensations are poorly understood, but suppression of scrambling is essential for preparing large quantities of pure trans-porphyrins. In this paper we describe a study of a wide range of reaction conditions for the 2 + 2 condensation that has led to refined synthetic procedures for the preparation of trans-porphyrins. 3. Adapted from : In the present paper, we focus on laser wake field acceleration in a new, highly non-linear regime. It occurs for laser pulses shorter than λ(p) but for relativistic intensities high enough to break the plasma wave after the first oscillation. In the present relativistic regime, one should notice that the plama wave fronts are curved and first break new the wave axis and for lower values than the plane-wave limit. This has been studied in 2D geometry in [14-17]. Here, we present 3D PIC simulations of two representative cases. The case (I) is just marginally above and the case (II) is far above the breaking threshold. [bg_faq_start] Good gap and fill signaling phrases are italicized.
1. “The factors that promote the scrambling process in MacDonald-type 2 + 2 condensations ….” “ a study of a wide range of reaction conditions for the 2 + 2 condensation that has led to refined synthetic procedures for the preparation of trans-porphyrins.”
2. This question is a little trickier! The authors use “In the present paper…,” then, “In the present regime…,” and finally, “Here…,” all of which sound like signaling words for filling the gap. But where is the gap? We have to look closely at what exactly is being said. It is true that the first statement appears to be somewhat of a gap fill, although they haven’t yet given us a gap statement. The authors go on to say “This has been studied in 2D geometry,” which brings us back to move 1(iii), identifying critical evidence from the literature. Thus, the is not explicit. It is a combination of stating that this concept has been studied in 2D, followed by announcement that the authors will study it in 3D. Although the first sentence (“… we focus on laser wake field acceleration…”) could also be considered part of the fill, because it comes before the gap statement and is also less descriptive, it functions more as an introduction to these moves.
3. According to the national monitoring program in Portugal, G. catenatum along the Portuguese coast during the 10-year period from 1995 to 2005.” to fully characterize the toxin profile of G. catenatum strains isolated from the NW Portuguese coast before and after the 10-year absence of blooms to
[bg_faq_end] |
[bg_faq_start] Find 3-4 primary research articles (not reviews) from reputable journals in your field. Underline the gap statement and circle the gap fill. Remember that not all papers follow this exact move structure, so if you can’t seem to find either of these moves, you might have to look carefully at different parts of the introduction and ask yourself: [bg_faq_end] |
Background Adolescents comprise one-sixth of the world’s population, yet there is no clear understanding of the features that promote adolescent-friendly services (AFS). The lack of clarity and consistency around a definition presents a gap in health services.
Methods The review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guidelines. We conducted a scoping review of peer-reviewed empirical studies to explore AFS in low-income and middle-income countries (LMICs) published between January 2000 and December 2022. The databases searched were CAB Direct (n=11), CINAHL (n=50), Cochrane Databases (n=1103), Embase (n=1164), Global Health Medicus (n=3636) and PsycINFO (n=156). The title, abstract and full text were double screened by three independent reviewers. Three independent reviewers assessed the study’s quality using the Joanna Briggs Initiative Quality Appraisal and Cochrane Risk of Bias 2 tools.
Results We identified the key components, barriers and facilitators of AFS. The following emerged from our review: a non-judgmental environment, culturally appropriate and responsive interventions and a focus on supporting marginalised communities often living in high-poverty settings. Using these components, we have extended guidance around a possible framework and tool assessing quality of AFS.
Interpretation As LMICs are heterogeneous and unique, it was assumed that the operational definition of ‘adolescent-friendly’ might vary depending on different contexts, but there must be core components that remain consistent. Possible limitations of our review include a lack of grey literature. Potential future implications include training healthcare providers, testing these attributes for service improvement and future development and localisation of policy guidelines.
Key highlights Our review has mapped the research framing of AFS and provided a comprehensive review of barriers and facilitators to implementing a holistic outlook of AFS set-up in a tightly controlled research and real-world context. Our paper is one of the few efforts to synthesise behavioural and mental health elements underpinning AFS.
All data relevant to the study are included in the article or uploaded as supplementary information. This is a review and all data have been presented in the paper.
This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ .
https://doi.org/10.1136/bmjgh-2023-013393
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Adolescent friendly services (AFS) are recognized as being central to making services accessible and acceptable to young people. However, distillation of evidence-informed adolescent friendly services and how mental health or behavioral components, and strategies inform and underpin these services is not clearly understood. Our scoping addresses this gap.
Our study provides in-depth examination of the barriers and facilitators of AFS while mapping the findings of key research studies from LMICs that address AFS in their intervention implementation and pulls together recommendations of key international adolescent health and development agencies. Our review findings are that AFS is about fostering a welcoming and non-judgmental environment, providing culturally appropriate and responsive services, and focused support for marginalised communities as it is especially needed within high-poverty settings. We would like to underscore that these services need strong and well-planned mental and behavioral health strengthening within LMICs to empower adolescents and youth.
There remains a gap between how academic research, policy guidelines and existing practices focus on implementation of AFS. Our review points to synergies that the fields need to create for effective and engaged adolescent friendly services in LMICs. Without cross-sectoral evidence-synthesis, service barriers in low resource settings and vulnerable adolescents youth cannot benefit.
Lessons from adolescent health fields suggest that adolescent mortality causes, especially in low-income and middle-income countries (LMICs), are largely preventable and treatable. 1 Thus, providing interventions during adolescence can promote positive health behaviours, which can equips individuals to maintain healthy lifestyles into adulthood. 1 Thus, health services that meet specific and differentiated needs of adolescents are increasingly relevant. 2 This scoping review is a partnership between a group of mental health researchers interested in investigating how responsive adolescent health services are to youth’s needs in LMIC contexts. We are also interested in identifying behavioural rubrics that define this responsive practice.
To address the increasing need for targeted youth interventions, WHO has outlined several characteristics and components to inform the implementation of targeted adolescent-friendly health services and interventions. In general, under the universal health coverage mandate, it has been recommended that the health services are fundamentally equitable, accessible, acceptable, appropriate and effective. The United Nations Population Fund (UNFPA) established ‘Four Keys’ for guiding the framework for action on adolescents and youth that entails: creating a supportive policy environment; facilitating gender-sensitive, life skills-based sexual and reproductive health (SRH) education; promoting a core package of SRH services; and fostering young people’s leadership and participation. The UNFPA framework aligns with global initiatives such as the International Planned Parenthood Fund (IPPF) and its guidance. IPPF’s definition of youth responsive service is defined as effective youth-oriented service, that is offered with trained providers; it is confidential and non-judgmental. 3 Furthermore, adolescent-friendly services should be available during times convenient for and accessible to all youths, such as after school, evenings or weekends. Another key recommendation of this guidance, especially Global Accelerated Action for the Health of Adolescents (WHO AA-HA), is to have services that are acceptable and engage adolescents and youth in behavioural change and health literacy as well as promotion effectively. The services should also have an effective referral system and encourage service users’ and carers’ involvement in the service development and intervention delivery. 1
Additionally, the WHO suggests the following eight global standard activities that ensure high-quality adolescent-friendly interventions: adolescents’ health literacy, community support, appropriate packages of services, providers’ competencies, facility characteristics, equity and non-discrimination, data and quality improvement, and adolescent participation. 1 Further, WHO has issued guidance for member states to carry out the implementation of adolescent programmes used in WHO AA-HA. 1 This guidance includes information for national policy-makers and programme managers when creating and implementing national-level programming aimed at adolescent health.
By comparing our review findings to the existing guidelines and scientific evidence on adolescent-friendly services, we aim to provide a rubric of adolescent-responsive components embedded within interventions within peer-reviewed empirical research studies. We will also compare these to commonly known global guidance on adolescent mental health programming, to address the needs of young people and improve health outcomes. The review will also aim to highlight commonly experienced barriers and facilitators in delivering such interventions in LMICs. As mentioned earlier, we are interested in knowing characteristics, strategies and conditions that were considered part of these services that made these adolescents friendly and those connected to mental or behavioural areas of health treatment, prevention or promotion.
The following research questions were central to this inquiry.
What are the key components of adolescent-friendly health interventions in LMICs?
What are the barriers and facilitators of adolescent-friendly health interventions in LMICs?
The search strategy to address definitions and exemplars of barriers and facilitators of adolescent-friendly intervention was designed with the help of a research librarian (CM) at the University of Washington. The search was completed on 22nd July 2021 using the following seven databases: CAB Direct, CINAHL, Cochrane Databases, Embase, Global Health Medicus, PsycINFO and PubMed. The search was updated on 15th December 2022 using the same search strategy. The retrieved articles were exported to Zotero referencing software, where duplicate records were deleted before the articles were uploaded to Rayyan.
The prescreening process involved using the WHO age criteria for adolescents, which included studies where participants were 12–24 years old. A study with a broader age range could be included if the participants were divided by age and the mean average age fell within the prespecified WHO age range. The search yielded studies published between January 2000 and November 2022. Only studies published in English were included as all the screeners (CJ, RS and JN) were fluent. The search included studies that involved participants residing in LMICs, as defined by the World Bank. The type of services described in the paper required some amount of meaningful human contact, which the authors defined as an intervention that was either delivered virtually or in person but not cash transfers only. The included studies required active youth involvement and needed youth to be the primary intervention target, so family-based interventions were not included. To attain a variety of adolescent-friendly interventions, studies based on the type of health problem were excluded; instead, a range of health interventions were investigated. The studies needed to include a health problem or related risk/protective factors of a specified health condition.
During the full-text screening, the inclusion and exclusion criteria expanded on the abstract and title exclusion criteria document. The additional criteria specified that the authors did not restrict based on the study design. Studies that described their intervention as ‘adolescent-friendly’ intervention by outlining features of the intervention that targeted youths were included. As this review aimed to extract descriptive data in narrative form, purely quantitative papers were excluded from the study as they did not include relevant outcomes. Studies required information on the barriers and/or facilitators of delivering an adolescent-friendly intervention in LMICs. The adolescent population included in the study needed to be living in an LMIC, not in a High Income Countries (HIC), as there would likely be significant contextual differences.
Each article was double screened during the title, abstract and full-text screening stage. After the screenings, the reviewers discussed the results and resolved discrepancies. The reasons for exclusion were noted for the full-text screening, which can be found in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow chart (see figure 1 ). Collectively, the reviewers coproduced a data extraction form, which gathered information on each study with a focus on distilling the adolescent-friendly features and identifying barriers and facilitators to the study’s implementation. The data extraction form ensured that similar information was summarised for each article. The PRISMA flow diagram outlines the selection process (see figure 1 ). A total of 6103 articles were identified. Once duplicates were removed, 4870 articles were included in the title and abstract screening process. This resulted in a further 4699 articles being excluded from the review. The remaining 171 studies were further screened in their full-text form, which removed an additional 165 studies. As a result, 14 articles were included in this systematic review.
Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow chart. LMICs, low-income and middle-income countries.
The quality of each included study was evaluated with the Joanna Briggs Institute (JBI) and Cochrane Risk of Bias 2 (ROB) Tools. We used the specific JBI and ROB 2 tools for the randomised control trials (RCT) and quasi-experimental study designs. The data extraction process was completed before the quality appraisal to allow the reviewers to familiarise themselves with the included studies. All the appraisals were conducted independently by two reviewers. Reviewers discussed the overall quality of each study and resolved discrepancies in the critical appraisal rating through consensus.
Tables 1 and 2 summarise the characteristics of the 14 studies in the scoping review. The studies were conducted in a range of geographical regions: Africa Region (n=6), South-East Asian Region (n=4), Eastern Mediterranean Region (n=2) and Region of the Americas (n=2). Interestingly, the included studies conducted in the Americas 4 5 and the Mediterranean 6 7 investigated interventions aimed at mental health and behavioural problems, while the studies from Africa focused on SRH. The included studies followed either an RCT (n=10) or quasi-experimental (n=4) study design. While most (n=11) of the studies focused on physical health, specifically pertaining to SRH (n=5), four studies addressed mental health topics, including resilience, 8 psychosocial well-being 9 and general mental health. 10 Moreover, two studies explored health behaviours, including nutrition 7 and diabetes. 4 One study involved education around communicable diseases, specifically hygiene and sanitation. 11 The studies varied greatly in the amount of participant information they reported. For example, the sample sizes ranged from 90 participants to 9654 participants; in total, there were data including 23 174 participants in this scoping review. Further, in one study, Flanagan et al did not report the number of participants included in their study; instead, the authors reported the number of clinic visits as 63 183 during the 6-month intervention period. Four of the included reported a mean age for participants. 4 7 10 12 For the remaining nine studies, the authors either reported the school grade equivalent or the age range of the participants in their study. 5 6 8 9 11 13–16
Key characteristics of the included studies
Characteristics of youth-friendly interventions
Seven studies adopted a theory of change model, where the authors evaluated an adaptation and modification to a particular intervention, envisioning how it would be delivered and sustained. 4 11 12 14 15
Seven of the studies followed a theoretical model, which aimed to explore theoretical rationale or mechanisms underlying the constructs further and evaluated the effectiveness of an intervention keeping those in sight. 5 7 10 12 14–16 The most common intervention delivery setting was a school (n=10), though two studies were conducted in a clinical setting. Hayes et al conducted their study in multiple settings: schools, community health units and community contexts. 15 Of the studies conducted at schools, four specified that the study was delivered in a classroom 5 8 9 11 ; however, six did not provide specific details on the delivery location 4 6 7 12 14 16 (see table 2 ).
Many of the studies (n=8) did not record the duration of training that the delivery agents received. 4 6 7 10 11 14–16 The remaining studies showed some variance ranging from 2 days to 2 weeks. 5 8 9 12 13 17 Mathews et al specified that the delivery agents received weekly supervision and support with session preparation after the 2-week training. 12 Furthermore, only Mathews et al indicated that the delivery agents received supervision. 12
The duration of the intervention delivery ranged from 1 session 6 to 10–15 sessions per year for 3 years. 15 Most studies reported the number of sessions and the duration in months or weeks. However, five studies only reported the number of sessions or duration of the intervention, such as the number of months or years. The minimal detail made it difficult to establish the comprehensiveness and intensiveness of the intervention. 4 7 8 10 11 One limitation of the included studies was uneven reporting of the number of sessions, the duration of each session and the length of the entire intervention. It made it challenging to compare resources, time and funding for the implementation of interventions in this setting.
The included studies highlighted components of their intervention that could be extracted to help develop a theme and consensus around a definition. The studies provided elements of a definition compatible with the guidelines established by the WHO 1 and UNICEF. 18 The peer-reviewed literature did not discuss the parameters presented in the grey literature but did incorporate key elements for adolescent-friendly services.
Table 3 illustrates how the policy directives from WHO and UNICEF map onto the specific adolescent-friendly interventions included in our review. The authors found that most (n=10) of the interventions met all of the criteria for the WHO Quality Assessment Guidebook. This suggests that most of the studies designed interventions that were equitable, accessible, acceptable, appropriate and effective for adolescents. Specifically, the studies described components of their interventions that meet the WHO guidelines. Hayes et al emphasised the need for local health workers to introduce school services to ensure medical support was ‘welcoming’ and ‘non-judgmental’. Several authors mentioned the importance of considering the specific cultural context. Jordans et al summarised the need for large-scale interventions to account for cultural differences. 9 Naghashpour et al also emphasised the need for an appropriate intervention to address cultural and traditional habits. 7 Similarly, Al-Sheyab et al spoke about a programme targeting healthy lifestyle barriers to tailor an intervention effectively. 6 Further, Mehreen et al ’s study described an intervention that relied on two theoretical models to understand the complex interplay of factors that impact adolescent health. 14 Specific to LMICs, the authors highlight the need for rigorous evaluation within resource-constraint, complex emergency settings. 9 Leventhal et al also expressed a need for greater support of marginalised populations and especially in high-poverty settings to strengthen assets. 8 Two studies, Mathews et al and Rockiki et al discussed the interventions’ aims of aligning with government policy. 12 16 Similarly, five studies involved collaborative research processes. 5 8 10 11 16 Finally, Rockiki et al and Ivanova et al used focus groups with youths to help inform their intervention development seeking adolescent feedback. 10 16
Assessing the included studies against the key policy framework recommendations
Pathfinder International’s Clinical Assessment of Youth-Friendly Services 19 is more specific than the WHO Quality Assessment Guidebook in distilling components of these services. 20 It includes the following 12 criteria: location, facility hours, facility environment, staff preparedness, service provided, peer education/counselling programmes, educational activities, youth involvement, supportive policies, administrative procedures, publicity/recruitment and fees. 19 Several of these criteria should have been discussed in the studies, for example, supportive policies, administration procedures and fees, which may be important considerations for the sustainability of an intervention that were missing in our identified studies. However, according to the WHO Quality Assessment Guidebook, 20 nearly all studies (n=10) met the criteria.
Similarly, several studies did not meet the WHO AA-HA 1 (n=4) and UNICEF Programmes 18 (n=6) criteria. These policy documents focused on supporting meaningful adolescent involvement, and the level of youth participation varied considerably across the studies. One intervention was as ‘peer-led’, which is an integral component of the WHO AA-HA recommendations for ‘Together’. 1 6 This recommendation defines ‘Together’ as a youth working for youth. 1 Additionally, a separate study by Ivanova et al included peer volunteers to help facilitate their intervention. 10 The authors emphasise the importance of involving individuals with experiences of living with HIV in developing their online platform, ELIMIKA, which aims to improve adherence to antiretroviral medication. 10 Similarly, Mehreen et al included peer leaders who acted as facilitators for delivering their intervention, and Flanagan et al used peers as an integral part of their referral system. 14 17 Morales et al highlighted that participants’ feedback was considered and incorporated into the implementation process. 4 This is similar to Hayes et al that used ‘short dramas’ and ‘role plays’ in delivering their intervention. 15 Mathews et al also included a theatrical component, which intended to lend youth an opportunity to share and communicate their knowledge. 12
The limitations of the studies identified fall into two categories: research design and set-up and participation-level barriers (see figure 2 and table 4 ). The research-level barriers included short study duration 10 16 ; small sample size 5 ; small geographical region; limited data collection, non-random allocation 15 ; and poor reliability of the psychometric instruments. 5 9 In contrast, the participant-levels outlined were poor literacy levels 8 ; COVID-19 restrictions impact social distancing and data collection; familial and personal barriers 6 ; limited access to technological resources 4 ; little input from students 11 and poor attrition due to negative attitudes. 15
Figure to visualise the barriers to studying a youth health intervention in low-income and middle-income countries.
Identification of barriers, facilitators and key features of adolescent-friendly interventions
The key facilitators included contextual considerations and emphasised meaningful stakeholder involvement (see figure 3 and table 4 ). Specifically, the facilitators highlighted: conducting community-based studies in rural areas 15 ; peer involvement; understanding the political and social environment 5 ; using a longitudinal study that provides visual aids 7 ; culturally adapting information for dissemination; and piloting to ensure that it is meaningful for participants. 8 The authors mentioned the importance of incorporating input from key stakeholders 4 11 ; ensuring accessibility 6 such as adopting a text messaging intervention 16 ; increasing knowledge of the topic 9 ; using school-based programmes as teachers can act as role models and schools can become healthier environments for adolescents. 14
Figure to visualise the facilitators of studying an adolescent health intervention in low-income and middle-income countries.
The JBI and the Cochrane RoB 2 tools were used to appraise the quality of the studies included in this scoping review ( tables 5 and 6 and 8 ). Of the 14 included studies, 10 were RCT, and 4 were quasi-experimental. The authors selected appropriate outcome measures for the context and samples selected in their studies. Eight included a participant follow-up measure to highlight the long-term effect of their intervention. Nearly all the RCTs and experimental studies (n=7) randomly allocate the participants to treatment groups and control groups. Four of the studies had a low risk of bias, while the other 10 had some concerns. The 10 studies that had some concerns regarding bias did not include information about concealment or discussed interventions in which concealment would not be possible or practical.
Johanna Briggs quasi-experimental quality appraisal
Johanna Briggs randomised control trials (RCT) quality appraisal
Cochrane risk-of-bias tool
One quasi-experimental study described a detailed follow-up process and analysed the data appropriately, and all the quasi-experimental designs included multiple outcome measures. Both the RCTs and quasi-experimental studies lacked the concealment of participants, delivery agents and outcome assessors which could impact the validity and reliability of the results. The RoB tool found that all 14 studies had a low risk of being biased by missing outcomes.
The consistent absence of concealment suggests a need to improve measures to counteract potential bias at all stages of the research process. Moreover, quasi-experiment studies included multiple outcomes of the interventions and provided robust information, which enabled a better understanding of the impact of the interventions. Additionally, the loss to follow-up may suggest attrition bias.
The included peer-reviewed studies incorporated key elements of adolescent-friendly interventions in line with the WHO 1 and UNICEF 18 standards (see figure 4 and table 8 ). Although not all the key recommendations were described in each included study, every paper discussed at least one key element from the WHO 1 or UNICEF 18 guidelines. One of the key elements extracted from the studies included a non-judgmental approach with an emphasis on privacy and confidentiality. 15 21 Additionally, interventions that were responsive and considerate of cultural differences were preferred. 7 9 This aligns with findings from previous reviews that identify confidential and culturally responsive care as an important consideration for adolescent-friendly services. 22–25 For a service to be sustainable, it may require collaboration with local and national governments, as demonstrated by both Mathews et al and Rockiki et al . 11 14 Peer support was also identified as a feature that augments youth’s experiences, specifically those living in high-poverty settings. 8 The importance of peer involvement in development aligns with the frameworks discussed and the findings of other reviews. 26–28 However, across the included studies, limited peer involvement was observed in the intervention design and delivery, despite the involvement of youth being considered an important element in nearly all the frameworks discussed in this review. 22 29 Although this appears to be a gap in the studies included in our review, we believe that the engagement of adolescents is critical in developing equitable policies programmes, and service systems, including evolving a framework and codesign for peer-to-peer support and facilitating youth-led interventions.
Network comparison of included studies and policy recommendations. The diagram illustrates how the included studies met the criteria outlined in the policy documents: Global Accelerated Action for the Health of Adolescents (WHO AA-HA), WHO Quality Assessment, UNICEF Second Decade and Path Finder Clinic Assessment. If all the criteria were met, we noted this relationship with a green line if all the criteria were met. If some criteria were met, we illustrated the relationship with a yellow line. As seen in the diagram, the WHO Quality Assessment and UNICEF Second Decade were most compatible with the included studies.
Key recommendations from the policy guidelines
One example of a country-level stance on youth engagement is from the UK’s National Health Service England which has outlined ‘key principles for effective peer support’. These include shared experience; accessible and inclusive; recognising strengths, values, needs and feelings of the individual; safe and authentic space; reciprocal relationship; support to find solutions, flexible and adaptive; and encouraging accessing to clinical advice and ensuring the person receives the right kind of support. 30 Organisations in LMICSs that embody these principles include the Naguru Teenage Information and Health Centre in Kampala, Uganda which trains peer health educators to connect with their peers through a call-in radio programme and Ogun State Adolescent Sexual and Reproductive Health Technical Working Group, through which youth representatives participate in the planning and implementation of ASRH-related policies, programmes and activities. 31
Moreover, meaningful engagement of adolescents is a critical component of WHO AA-HA principles and guidelines, which did not appear to be found in the included studies. Other reviews evaluating adolescent-friendly services determined that adolescent involvement in the development, delivery and evaluation is important in improving the acceptability of interventions targeted at youth, challenging social and cultural norms and promoting behaviours associated with help-seeking. 22 29 32
The elements extracted from the included studies contained the following WHO principles—focus on prevention and treatment. 33 This definition also confers with the WHO-AA-HA guidelines of confidentiality/non-judgmental, training of providers and accessibility, which includes community or school-based intervention. Although all four of these guidelines refer to the state and national levels of public health planning, the authors saw the benefit of including specific guidelines for individual community-level interventions. The noted discrepancy in the number of young people enrolled in schools in LMICs limits the reach of these interventions. 34 This may advocate for expanding adolescent-friendly services in settings beyond the classroom, to communities and spaces where adolescents are likely studying, working or generally found. Out-of-school adolescents are one neglected, vulnerable population that would need more tailored community-based intervention. 35
Additionally, we found that the studies varied in their structures for adolescent engagement, for example, the duration and number of sessions; we were unable to draw conclusions about the quality of these interventions. However, an important consideration of working in LMICs, and in mental health in general, is the resource constraints, which advocate for task-sharing approaches. A previous review identified both intersectoral collaboration and task-sharing approaches as facilitators of youth-friendly services LMICs. 36 Further, the feasibility and practicality of implementing a service might highlight trade-offs, that is, the barriers identified in our review, for example, short study duration, 10 16 poor reliability of the psychometric instruments, 5 9 poor literacy levels 8 and familial and personal barriers. 6 Thus, future researchers may need to adapt to their setting to ensure the sustainability of their interventions.
Moreover, our review identified the barriers and facilitators to service delivery and interventions in LMICs. The key facilitators included contextual considerations (ie, political and social environment) emphasised meaningful stakeholder involvement and made information culturally adapted. These facilitators emphasise the need to understand the context and involve key stakeholders from the project’s onset. To ensure a sustainable youth-responsive intervention, future researchers must use a dual approach combining bottom-up and top-down approaches to support the targeted health concerns.
The authors conclude that additional research is needed to evaluate strategies to support the scale-up and sustainability of adolescent-friendly interventions in resource-constrained settings. Previous literature has outlined the following challenges to implementing adolescent-friendly services in LMICs, including training, infrastructure, service user involvement, evaluation strategies and support for healthcare providers. 26 These considerations resonate with the findings of our scoping review, as several studies also reported the short research duration of the intervention. 5 7 9–12 16 It would be critical for future research to explore ways key stakeholders, including service users, could be involved in the research process, from proposal drafting to implementation.
The WHO’s AA-HA outlines guiding priorities for adolescent health on the level of national policy-making. 1 The development of a tool based on the core components outlined in this review to create a standardised baseline of requirements for adolescent-friendly care could be a reasonable next step to parse further which additional features are barriers and facilitators for adolescent-friendly care. Figure 5 presents some guidance on development of a tool keeping our review and policy guidelines in mind. The attributes of ‘together’ with and for adolescents, through relevant contextual ‘priority setting’ and ‘leadership’ driven processes can enable a system that can transform adolescent health across generations to blend into population health. Figure 5 also provides pointers to a checklist that this tool must cover in terms of cross-sectoral domains of adolescent health programming. While such a standard would necessitate the consideration of geographical and service-type specific factors, it could act as a starting point for defining positive and negative features of care.
Key attributes and guidance for a possible tool assessing adolescent-friendly services and/or intervention development.
Possible limitations of this review include an absence of information extracted from grey literature and frameworks that were not formally published and publicly available on this theme. This may have resulted in missing features of adolescent interventions. Conversely, the reporting of the methodology appeared to have influenced the quality of the studies and the detail of data available.
This scoping review attempted to identify an operational definition for an ‘adolescent-friendly’ intervention. To synthesise the literature to an operational definition, we created a rubric based on the similarities across studies. The included studies contained key features of adolescent-friendly interventions; these components included fostering a welcoming and non-judgmental environment, providing culturally appropriate and responsive services, and focused support for marginalised communities within high-poverty settings. 4–12 15 16 Furthermore, the included studies did not detail the barriers and facilitators of developing or implementing their intervention; instead, they appeared to focus on the strengths and weaknesses of their study. The implementation of the interventions including youth-friendly services needs to become a guiding principle to evaluate acceptability, effectiveness and sustainment of interventions.
Patient consent for publication.
Not applicable.
Acknowledgments.
MK would like to acknowledge the support of Dr Ogedegbe and IEHE towards publication of this paper.
CJ and RS are joint first authors.
Handling editor Helen J Surana
X @manasikumar229
Contributors MK conceptualised the review. KV-C, CJ, RS, JN and MK designed the detailed search strategy with support from CMa and AM. CJ, RS and MK developed the first draft and subsequently all authors including CMo and SP reviewed and edited the final review. All authors read, commented and agreed with the final version. CJ and RS act as guarantor and MK is responsible for the overall content of the review.
Funding RS’ work on the review was funded by the Mary Gates Endowment at the University of Washington. MK was supported by NIMH/FIC R33MH124149-03 and K43TW010716-05.
Competing interests None declared.
Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.
Provenance and peer review Not commissioned; externally peer reviewed.
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Here are the key takeaways: A research gap is an unanswered question or unresolved problem in a field, which reflects a lack of existing research in that space. The four most common types of research gaps are the classic literature gap, the disagreement gap, the contextual gap and the methodological gap.
Here are some examples of research gaps that researchers might identify: Theoretical Gap Example: In the field of psychology, there might be a theoretical gap related to the lack of understanding of the relationship between social media use and mental health. Although there is existing research on the topic, there might be a lack of consensus ...
The identification of gaps from systematic reviews is essential to the practice of "evidence-based research." Health care research should begin and end with a systematic review.1-3 A comprehensive and explicit consideration of the existing evidence is necessary for the identification and development of an unanswered and answerable question, for the design of a study most likely to answer ...
BACKGROUND. Well-defined, systematic, and transparent methods to identify health research gaps, needs, and priorities are vital to ensuring that available funds target areas with the greatest potential for impact. 1, 2 As defined in the literature, 3, 4 research gaps are defined as areas or topics in which the ability to draw a conclusion for a given question is prevented by insufficient evidence.
These are gaps in the conceptual framework or theoretical understanding of a subject. For example, there may be a need for more research to understand the relationship between two concepts or to refine a theoretical framework. 3. Methodological gaps. These are gaps in the methods used to study a particular subject.
Step 1: Identify your broad area of interest. The very first step to finding a research gap is to decide on your general area of interest. For example, if you were undertaking a dissertation as part of an MBA degree, you may decide that you're interested in corporate reputation, HR strategy, or leadership styles.
Identifying a research gap has many potential benefits. 1. Avoid Redundancy in Your Research. Understanding the existing literature helps researchers avoid duplication. This means you can steer clear of topics that have already been extensively studied. This ensures your work is novel and contributes something new to the field.
About this video. Researching is an ongoing task, as it requires you to think of something nobody else has thought of before. This is where the research gap comes into play. We will explain what a research gap is, provide you with steps on how to identify these research gaps, as well as provide you several tools that can help you identify them.
Research gaps prevent systematic reviewers from making conclusions and, ultimately, limit our ability to make informed health care decisions. While there are well-defined methods for conducting a systematic review, there has been no explicit process for the identification of research gaps from systematic reviews. In a prior project we developed a framework to facilitate the systematic ...
Literature Gap. The expression "literature gap" is used with the same intention as "research gap.". When there is a gap in the research itself, there will also naturally be a gap in the literature. Nevertheless, it is important to stress out the importance of language or text formulations that can help identify a research/literature gap ...
The theoretical gap is the type of gap that deals with the gaps in theory with the prior research. For example, if one phenomenon is being explained through various theoretical models, similar
A research gap is a specific area within a field of study that remains unexplored or under-explored. Identifying a research gap involves recognizing where existing research is lacking or where there are unanswered questions that could provide opportunities for further investigation. Understanding research gaps is crucial for advancing knowledge ...
The following steps can help with optimizing the search process once you decide on the key research question based on your interests. -Identify key terms. -Identify relevant articles based on the keywords. -Review selected articles to identify gaps in the literature. 3.
A research gap is a question or a problem that has not been answered by any of the existing studies or research within your field. Sometimes, a research gap exists when there is a concept or new idea that hasn't been studied at all. Sometimes you'll find a research gap if all the existing research is outdated and in need of new/updated research ...
A research gap, in a certain area of literature, is defined as a topic or subject for which. missing or insufficient existing body of knowledge limits the ability to reach a conclusion. It. may ...
Systematic reviews, in addition to summarizing the evidence, generally also discuss needs for future research. However, in contrast to the methods of the systematic review, future needs are not identified systematically. There is limited literature describing organizing principles or frameworks for determining research gaps. We developed and pilot-tested a framework for the identification of ...
PDF | Miles (2017) proposed a taxonomy of research gaps, built on the two previous models. It consists of seven core research gaps: (a) Evidence Gap;... | Find, read and cite all the research you ...
Aug 25, 2023. Introduction. A research gap refers to an unexplored or underexplored area within a particular field of study where there is a lack of existing research or a limited understanding of ...
the recent literature on online databases. types or classification and definition of research gaps and the The first search on Google Scholar using the broad keywords "research gap", and "types of research gaps" yielded search results of 4,880,000. When the phrase "identifying research gaps" was entered into the search, a total
Research gap definition. A research gap exists when: a question or problem has not been answered by existing studies/research in the field ; ... For example, suppose your research gap is on the work-life balance of tenured and tenure-track women in engineering professions. In that case, you might try searching different combinations of concepts ...
Stakeholders rated 19 PTSD-related research gaps and suggested an additional 5 topics for evidence review, addressing both preventions as well as treatment topics. Mean ratings for topics ranged from 1.75 to 3.5 on a scale from 0 (no impact potential) to 4 (high potential for impact). Thus, although identified as research gaps, the potential of ...
Some phrases you can use to indicate your gap "fill:". "We therefore analyzed…". "In this study, we investigated…". "Therefore, the goals of this study are…". "In this paper, we report…". Remember-always keep your voice professional! Colloquial phrases such as "we looked into" or "we checked if" should be ...
In the philosophy of mind, the explanatory gap is the difficulty that physicalist philosophies have in explaining how physical properties give rise to the way things feel subjectively when they are experienced. It is a term introduced by philosopher Joseph Levine. [1] In the 1983 paper in which he first used the term, he used as an example the sentence, "Pain is the firing of C fibers ...
Background Adolescents comprise one-sixth of the world's population, yet there is no clear understanding of the features that promote adolescent-friendly services (AFS). The lack of clarity and consistency around a definition presents a gap in health services. Methods The review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for ...